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KMID : 0360319940260050778
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 5 p.778 ~ p.785
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Concomitant Boost Radiotherapy in Clinical Stage III Non-Small Cell Lung Cancer
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Abstract
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A single treatement arm, phase I/Ⅱtrial was performed to determine the tumor response to concomitant boost radiotherapy and to assess the toxic effects of this techneque in patients with stage Ⅲ NSCLC.
Between 1991-1992, 52 patients with stage ⅢNSCLC were treated according to the concomitant boost technique. The large fields including primary mass and mediastinum received a dose of 54Gy in 30 daily fractions. The boost dose(13 Gy) was
administered
concomitantly with the last ten fractions of the large fields treatment, with a 6 hour interval. The maximal allowed dose to the spinal cord was 45Gy.
At a median follow-up of 13 months, complete remission was achieved in 15 patients (28.8%) and a partial remission in 28 aptients(53.8%). The overall survival rate at 2 year was 19.9%. The median survival time was 13 months. The survival rates
were
28%
and 16% for the complete responders and partial/non responders. Grade 1 and 2 esophagitis occurred in 86.5% and 13.5% of the patients. respectively. The clinical or radiologic condition of 38 patients (73.1%) was compatible with radiation
pneumonitis
but no patients showed severe symptoms. Late complications have been limited to radiologically detected lung fibrosis in 12(23.1%) patients.
The results so far appeared to be better than the outcome of conventional radiotherapy. Its real value will be determined in a prospective randomized study.
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KEYWORD
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